邓文斌

  • 2016年任药学院(深圳)院长,教授、博导 。2006年起任美国国立卫生研究院等基金会的评审专家,多种重要国际期刊的审稿人,获得美国国立卫生研究院等单位15个基金项目[LN1] 
  • 学科专业:[LN2] 药理学、生物化学、分子医学
  • 研究方向:神经胶质细胞及干细胞研究、新药研发
  • 邮箱:dengwb5@mail.sysu.edu.cn
  • 代表性论文:[LN3] 
  1. Jiang P, Chen C, Liu X, Pleasure DE, Liu Y, Deng W**. (2016) Promoting oligodendrogenesis by human iPSC-derived immature astroglia via increased TIMP-1 secretion. Cell Reports, 15 (6): 1303-1315. doi: 10.1016/j.celrep.2016.04.011. PMID: 27134175.
  2. Chen C,Jiang P, Xue H, Peterson SE, Tran HT, McCann AE, Parast MM, Li S, Pleasure DE, Laurent LC, Loring JF, Liu Y, Deng W*. (2014) Role of astroglia in Down’s syndrome revealed by patient-derived human-induced pluripotent stem cells. Nature Communications. 5:4430 doi: 10.1038/ncomms5430 (2014).
  3. Jiang P, Chen C, Wang R, Chechneva OV, Chung S, Rao M, Pleasure DE, Liu Y, Zhang Q, Deng W*. (2013) hESC-derived Olig2+ progenitors generate a subtype of astrocytes with protective effects against ischemic brain injury. Nature Communications, 4: 2196 doi: 10.1038/ncomms3196 (2013).
  4. Daugherty DJ, Selvaraj V, Chechneva OV, Liu X, Pleasure DE, Deng W*. (2013) A TSPO ligand is protective in a mouse model of multiple sclerosis. EMBO Mol Med, 5 (6): 891-903.
  5. Jiang P, Chen C, Liu X, Selvaraj V, Liu W, Feldman DH, Liu Y, Pleasure DE, Li, RA, Deng W*. (2013) Generation and characterization of spiking and nonspiking oligodendroglial precursor cells from embryonic stem cells. Stem Cells, 31 (12), 2620-2631, doi: 10.1002/stem.1515.
  6. Liu Y, Jiang P, Deng W*. (2011) Olig gene targeting in human pluripotent stem cells for motor neuron and oligodendrocyte differentiation. Nature Protocols, 6 (5): 640-655. The first two authors contributed equally.
  7. Deng W*. (2010) Neurobiology of injury to the developing brain. Nature Rev Neurol, 6 (6): 328-336.
  8. Deng W*. (2009) PARylation: strengthening the connection between cancer and pluripotency. Cell Stem Cell, 5: 349-350.
  9. Deng W, Wang H, Rosenberg PA, Volpe JJ, Jensen FE. (2004) Role of metabotropic glutamate receptors in oligodendrocyte excitotoxicity and oxidative stress. Proc Natl Acad Sci USA 101, 7751-7756.
  10. Deng W, Rosenberg PA, Volpe JJ, Jensen FE. (2003) Calcium-permeable AMPA/kainate receptors mediate toxicity and preconditioning by oxygen-glucose deprivation in oligodendrocyte precursors. Proc Natl Acad Sci USA 100, 6801-6806.